Yep....I have a Ceiner for my Colt and Ruger Commander .45s, a Marvel for the Gold Cup but which also fits several other .45's (a WWll Remington-Rand, a 5" Ruger, and another Series 70 Colt), also a Colt Sliding chamber upper for the Gold Cup.
Of them all, the Marvel is the most accurate...good enough in fact for NRA Bullseye competition. It'll hold < 1.5" at 25 yds all day long with a variety of ammunition, CCI Mini-Mags being the most trouble free. But the Ceiner is a close 2nd, and both are more accurate than the original center fire uppers.
When I got into Sigs, I also bought a .22 upper for the P226 Mk25 and have used it extensively to practice that difficult DA/SA transition between the 1st and 2nd shots. It's helped...and I found that, as with the 1911's, the .22 unit was at least as accurate as the center-fire.
I find all of them of great value, now that the price of .22's has come down, and I've used the new lower prices to really stock up. For me, they're most valuable to teach new shooters the fundamentals of marksmanship, safety and short gun handling without the recoil, muzzle blast and expense of the big calibers. Too, they all work well for me to re-visit the fundamentals of trigger manipulation, sight alignment & picture, and grip uniformity as well as draw/presentation technique...hell...they're just a lot of fun when you get stale with the big stuff.
For the long guns, I've got an expensive upper that fits my Colt Match Target AR that I've never been able to get shooting right...it's been back to the nationally known gunsmith twice but with no success. It's a match barreled, superbly accurate gun too...pity.
Back when I was still competing in classic Service Rifle, National Match Course matches, I managed to find a Springfield 1922 M2 (.22 understudy for the '03 Springfield) that's been a lot of fun, though less useful for practice in rapid fire than I thought. (the clip change/reload during sitting and prone rapid fire is the key to an '03 if you want to be competitive) But the gun is fun to shoot. Built in 1931, with its Lyman #48 receiver sight, it's capable of 1" gps at 50 yds if my eyes are cooperating. Not too bad for an 86 year old rifle steered by a 71 year old shooter, I think you can agree?
So I've found the .22 understudies for my center-fire guns of value, fun to shoot, and inexpensive if your ammunition supply holds up. They're worth the money spent, giving you the identical grip and trigger for practice when the larger caliber upper is impractical.
HTH's Rod and forgive the ramblings....