I've owned quite a few vaqueros and I could always find a load that shot to point of aim, even if it wasn't the load I wanted to shoot.
Some pistols have shot to the right or left and people helpfully pointed out I was holding the gun wrong or had crap trigger control even though it shot to the same point of aim shooting right or left handed or two handed with either hand dominant all from sandbags. Rather than fight about it, just move the sights.
Smith and Wesson lost me when I paid top dollar for a model 317 Kit Gun. Light weight and cute as a button, I could not hit the paper at 50 feet, even with the sight screwed all the way to the left. The group size was appalling. Sent it back. Cost me $50 in shipping.
It came back spraying an appalling group but with the rear sight centered, with a note explaining that the short sight radius meant the inaccuracy was me. My TT Olympia clone had about the same sight radius and I could shoot the 10 ring all day from sandbags. They lost me then and there. I would consider and older S&W but won't buy a new revolver from them ever again. That little (bit of fecal matter) cost a lot for a .22 and I expected it to be a shooter. I learned.
Dealing with sights that are off is too hard for me as I might shoot from 5 feet to 50 yards and I like hitting what I shoot at.