Not sure what you call large hands. I wear s size 8.5-9 glove, depending on the maker...
Had one of those ages ago, got rid of it as I"m not into .25s and for me it was a "two finger pistol" and a small one, at that.
THe trigger was heavy, there are about no sights, there is almost nothing to hang on to, and very little to hold to operate the slide. Plus the spring is kind of stiff. AND you have to hold it in just the right way or it won't work, due to the grip safety.
Its a finely executed example of what I consider a poor idea, and I wouldn't want to bet my life on one. if you're a collector, you ought to have one, just as an example of the type.