Yes, I started shooting serious numbers of .22LR about two years ago. I still take a .22LR to the range every time I go.
Yes, I reload, and enjoy shooting .45 acp, .357/.41 Mag, .45LC, etc.
These days primers cost about .035 cents each, and powder costs money...
22LR rounds cost about .027 each (although a lot of the ones I own were bought at about 1/2 that price, I tend to look at replacement cost)...so I'm not sure how "rimfire is somewhat pointless in my case."
To each his own.