I'm actually working with some screwbean mesquite for a rifle, right now. Like many varieties of cedar, it is known to have some compounds that don't necessarily get along with some people or animals.
I spent almost a year (on and off) fondling the stocks, rough shaping with a rasp or saw, and drilling holes, with no issues.
But, once I started sanding and producing fine particles... Everything went nuts.
My sinuses would get inflamed, my eyes would itch and water, my hands would swell a bit, and I'd start itching all over.
The first couple of times, I didn't connect the dots. But, once I did, I started washing my hands and face regularly - even stopping what I was doing to wash, and return to the same job - wearing a mask if it didn't interfere with the process, and showering after I dusted, swept, and gave the dust time to settle.
If I don't wear a mask, my sinuses and eyes get a little irritated. But, the itching and swelling are at least reduced and generally not noticeable.
It still doesn't bother me to fondle, test fit (to my shoulder), and gently caress that sexy piece of wood, though.
...It's just the sanding dust that gets to me. And once the stocks are fully finished and sealed, I'll probably forget about the whole thing and never have a problem again.