as stated earlier, you should measure the headspace of a fired case (with RCBS precision mic or Hornady's headspace tool) from this gun and compare the measurement to factory rounds of all the brands you have available. If any gun has issues with firing factory ammo (especially Weatherby factory ammo because it consists of top quality components), i would have to assume there is an issue with the chamber/gun and would have a reputable gunsmith inspect it.