Fubsy,
The Inuit are known to take polar bear with .22 LR or .22 Hornet.
That certainly doesn't make those "all around" calibers.
I think the following criteria apply to an "all around" rifle.
1. Powerful enough to take mule deer, elk, moose, or perhaps if you really want to push it, a grizzly bear.
2. Flat shooting enough that it will serve well in the open lands of the west, where 300 yard shots on antelope aren't uncommon.
3. No so powerful that it needlessly wastes meat on a 100 to 120 lb. whitetail.
4. A rifle that you'd be willing to take groundhog hunting, just to stay in practice for hunting season.
5. A rifle that doesn't recoil so much that you're afraid to shoot it.
All of the calibers I listed in my first post qualify, in my opinion. The .338 is pushing the upper boundaries, while the .25s/6mms are beginning to want for power on the larger animals.
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Smith & Wesson is dead to me.
If you want a Smith & Wesson, buy USED!