Merry Christmas, HistoryJunky,
When I was in the omniscient days of my youth, I bought a .44 Mag handgun. Don't ask me why I bought it. I cannot remember. There must have been a good reason because when I was young there wasn't much that I did not know. Long story short: that weapon was too freaking powerful for me to even remotely attempt to master. If anything, that damned gun owned me. Coming to the reality that I should have fired a .44 Mag before buying one, I had to reconcile the fact that when I bough it I wasn't as smart as I thought I was. Progressing along the bright guy continuum, I wised up and sold it.
I have fired 3 full-power .454 Casull rounds through a Freedom Arms revolver. Freedom Arms manufactures excellent handguns. After the third shot, I set the gun down and never touched it again.
It's one thing to want a big handgun. It's another thing to want to shoot it. I know that a small percent of big handgun owners can actually shoot them accurately and without fear of recoil. I am not such a shooter. The most powerful magnum I can shoot with proficiency is a .357 Mag, & that's out of an "L" frame revolver or bigger. You couldn't pay me to shoot a "J" framed revolver with .357 Mag ammo.
You might want to borrow or rent a copy of the big bore handgun you're thinking of buying and see if it's for you.