MattMPhoto, for what it’s worth, I’ll throw my 2 cents in. I’m in South-Central PA, about an hour south of Scranton and East of Harrisburg. I’m fortunate to have a membership in a hunting club where my whitetail hut observes a field out to 350 yards. Nevertheless, my shots have been 90 to 250 yards. I’ve hunted Elk out west, hogs and deer in the south, but mostly deer in PA.
I’ve used .270 Win successfully at least 50% of the time with 140gr SST and Hornady 150gr spires. I’ve also used .25-06, .300 WSM, .300 Win Mag, .270 WSM, 7mm Rem Mag, 7mm STW, .338 Win Mag, and 6.5 Creedmoor. I harvested a nice 8-pointer on the run at 90 yards with the 6.5CM, and it does work nicely on targets out to 1000 yards, as I hit a 12-oz paint spray can, dead-center, at that distance.
I had a “failure” on an elk at 300 yards with a 7mm Rem Mag using a 175gr Spire. The elk went down but when the guide and I approached to process and cart it out, it got up and continued to rise and fall downhill. The guide made the final kill with a handgun since I was advised to leave my rifle in the truck. The bullet broke the shoulder but didn’t penetrate enough to provide lethality. My next trip was with a .388 Win Mag and a 215gr spire at 200 yards did the trick with one shot.
If I were to pick my favorite for PA, it would have to be the .270 with 150gr spire. But that’s like my best trout fly is the one that I use most often.