Research
Keybear,
There are a lot of different anaerobic sealant products from Locktite. Have a look at their website and technical documentation for the products.
As mentioned previously, clean is critical for Locktite. Remove every trace of oil and or grease from the threads of both the fastener, and of course the threaded hole.
Typical threads are designed for 75 % engagement. In addition to "locking" the threads the proper grade of Locktite can strengthen the threaded fastener by filling in that 25% space between the threads.
Your nose is your friend when it's time to remove a screw where Loctite has been used. Esp. for firearms I use a sacrificial screwdriver bit that fits the screw very closely. Use a small torch to heat the sacrificial bit to transfer heat to the screw itself. A sweet odor will be your cue quickly switch bits and loosen the screw. Most times the hot sacrificial bit is still strong enough to turn the screw.
But then you killed a Freedom arms and a Contender....I can't even think of any handguns that are stronger than those.