"In all honesty, flatter shooting is of little benefit if you do not know the exact distance to the target and how much drop your bullet will have at that distance."
I see what you are saying, but the flatter trajectory without a doubt gives you more leeway no matter the range. You can look at extremes like a 22-250 v. 45/70 to get the point, but it is just as valid when comparing a 454 v. 460. Maybe the 454 drop gives you +- 5 yards at a 200 yard target and the 454 only gives you 3(my guess is both give you a bit more), but it is still going to give you more leeway. Probably enough leeway to make up for a the environmental issues except crosswind which is pretty much irrelevant. I guess a headwind or tail wind would come into play.
I have made several thousand shots at unknown distance inside 250 yards and think I am reasonable good at estimating the range to within a few yards.
I have a box or two of gold colored plastic trophies in my parents basement to prove it, even if all the little gold golf clubs are long lost
I also have a halfway decent range finder I bought for shooting my 22-250 at a little longer ranges. I carry it when I hunt and range landmarks in my shooting lanes when I set-up.
If I was looking at a revolver I might agree with you more as there is a significant price difference, but the Encore barrels all cost the same.