The main drawback I see is the recoil. This is coming from someone with a bolt action 444 Marlin, so your results may differ. But if the cartridge is capable of it, why not? A good barrel, good reloading technique and good bullets can get you there. Everybody's got an idea of what works or what they want to shoot, so try it. If it doesn't work, the worst part is living down the stories people will tell about the crazy guy that showed up with a 450 BM.