I shoot .45 Colt in a Red Hawk. When I get a projectile/powder combination without data, I do the following:
Factory Duplication load x [(Factory Dupl. Bullet Wt.)/(New Bullet Wt.)] = starting charge.
MY factory duplication load is 8.0/Unique/255 SWC. So,
8.0 gr. x [(255 gr.)/(300gr.)] = 6.8 gr. So MY starting load would be 6.8/Unique/300gr. Cast.
I think someone else suggested 7.0/Unique/300, and I would have no problem with using THAT as a starting load.
Take note of a few things:
1.) I made this approximation using a large (for pistols) capacity case, with very modest working chamber pressures.
2.) MY approximations will be loaded and shot in a Ruger Red Hawk, while your revolver is a Ruger SRH. Both revolvers are strong enough for the .44 Mag cartridge, so a slightly boosted .45 Colt load isn't going to wreck them.
3.) I approximated cast bullet to cast bullet. Had your projectile of interest been jacketed, I would have tried to approximate from loading data using jacketed bullets.
4.) This approximation is NOT fool-proof. Take a step back and see if the approximation you calculate seems reasonable, and check it against any appropriate information, or with someone who is more experienced than you.
5.) Like someone's signature line on here says, "If you don't know what you're doing, DON'T!" Ask around until you get a better feel for the task at hand.