OK. There's some peculiar stuff going on when you shoot a short autoloader cartridge from a long revolver cylinder.
FIRST, I don't think the 45ACP is a good idea in the converted front-stuffers...not unless I knew a lot more about the metallurgy being used in the 1858 clones by Pietta and Uberti. I would be curious enough to get a Rockwell test done on the frame as that would tell a lot.
Let me confine my comments to post-WW2 Colt SAAs, Ruger's New Vaquero, DA S&Ws and other guns known to be tough enough for full-power jacketed 45ACP.
The 45ACP has some interesting advantages over the old 45LC, to wit:
* For factory defensive loads, the 45ACP is still getting the very latest bullet tech from Federal, Winchester and others. Federal's devastating HST "police sales only" critter ships in 45ACP as does the barrier-penetration beast Hornady calls the "Critical Duty". There are others worth mentioning. These loads don't ship in 45LC.
* Reloading is faster and extraction is faster - DA or SA. On a DA you can use moons. On an SA you can thumb rounds into the loading gate out of 1911 mags or the like - not exactly "the cowboy way" but it works. And the tapered rounds extract faster and more reliably.
* Weirdest of all, the ACP gets a speed boost of sorts when traveling through the long smoothbore section of the cylinder that is "tight to the bullet". I don't know how much in a 45. I did some research on the 9mmPara (assuming a real 9mm-spec barrel as opposed to .357) and found that a 2" "snubbie" S&W was producing velocities on par with a 4" barrel Glock. That's impressive because a Glock has no barrel-to-cylinder-gap AND uses a nice poly-rifled hammer-forged barrel that tends to "spit fast". I would not have believed they were a wash but tests show otherwise. I believe this is due to the "tight smoothbore" going on for about 3/4" of travel, with zero (or close to it) gas losses via blowby. Now again, I don't know how much the boost is on a 45ACP in a full-sized gun, but I'd be willing to bet that a Ruger NewVaq in factory 45ACP with a 4.68" barrel is going to spit out rounds faster than a 5" 1911. Maybe a lot faster. Will it make up for the reduced case capacity vs. the 45LC? I doubt it, but...it's not impossible in similar weight loads. In the heavyweights suitable for four-leggers the 45LC will likely still pull ahead but...not for social use I don't think. Not given the slug development that's gone into 45ACP police use rounds...
It was this research that told me that I'd be happy converting Maurice the FrankenRuger NewVaq to a true 9mm complete with Douglass .355" barrel from a 357. True, power was going to drop but in terms of "social use" the per-round effectiveness could be bolstered by the police-grade 9mm+P/+P+ rounds that a former 357 can eat all day long and have been stacking up well against most .40S&W.