you gotta carry it
A woods gun means to me you are going to carry it, likely afoot, some distance in the woods. To me, an N-frame Smith is about the limit size wise, of a woods pistol, and ideally, it would be of the slimmed down Mtn gun configuration.
Also, unless I was in grizzly or big cat country, I would not run the thing full power, but more in the neighborhood of mid range power.
I've never shot a DE but I've handled one it could best describe it as pondorous. So too a Super Redhawk and a BFR in .500. Again, for me, an N-frame Smith, or a Super Black Hawk, w/ 4" tube , is about the limit in portablity. Anything bigger, I'd just as soon carry a carbine.