In most calibers, I like the heavier or medium standard weight bullets. In .38/.357 I prefer 158gr or 125gr over 110gr. In .45ACP I prefer 230 or 185gr over some of the lightweight bullets out there. In .40S&W I prefer 180 or 165 gr. In all those cases, with some specialized exceptions (185gr .45 for shorter barrelled guns), I prefer the heavier bullet, with the medium being my 2nd choice. 9mm is my only exception with the medium grain bullet being my preference and typically the 115gr has been my 2nd choice (though I'm thinking about switching to the 147 over 115, probably keeping the medium weight bullet as my 1st choice).