MLeake,
I have a couple of 642's with the old standard S&W wood panels and a Tyler T grip on them. These keep the gun to pretty much its smallest size, and yet its still very shootable and comfortable to shoot with. I've tried the other types of grips, but always came back to the "old school" set up. I never understood why people insist on buying "small" guns, only to make them bigger so they can shoot them. Just never made sense to me.
These days, I use Speer 135 grain Gold Dots in mine for carry, and shoot my reloads (158 grain LSWC's over 4.4 grains of 231 at around 850fps) for practice. About a box of 50 is all I can take anymore, and my hand is sore for a couple of days after. Still, even though I rarely carry one anymore, I practice a couple of times a month with one, just to stay on top of it.
You really do need to shoot/practice with loads of an appropriate power level to stay on top of them too. Wadcutters reall just dont cut it, so to speak.
Practice wise, I base what I'm doing on how I do it, and with carry guns, thats drawing from where I normally carry it and shoot the targets (usually the human photo type, not bulls eyes) at varying ranges and often while moving. Normally, my 10-15 yard hits on target with my 26 are as tight or tighter than my hits on target at 5-7 yards with my 642's. All will work regardless, but I just find I'm tighter and faster, especially with follow ups with the 26.
If I'm leisurely shooting at a traditional bullseye target at the same distances, my groups are very similar, with either gun.
Its not that the small revolvers are inaccurate, far from it, its just for me, they are not as accurate or easy to shoot as quickly or well with, as the autos.
But hey, to each his own. Carry what you shoot the best with and are more comfortable with.
Oh, and Im a little older than you, but I still get around pretty good.
I'm 55, 5'6" 170# with a 33-34 waist, and work and play physically outdoors most of the year. I'm sure I'll still shoot the snubbies as long as I can shoot any of them, but I've given up on the little 357's, as I dont really see the point. For all the same reasons above, and more, I think +P+ out of a 9mm like the 26 is the better solution.