I am going to answer anecdotally with my own evidence to back it up. I think 38spl is a fantastic EDC for people who can handle to shoot 38spl over other, more powerful options. About three years ago, I got into ballistics when really getting into hand loading. 38spl is NOT the best choice IF you can handle a stronger caliber, and ALOT has to do with the firearm you plan to use. A revolver with a three inch or longer barrel is wildly different than a snubbie with a less than two inch barrel.
I started my EDC adventure with 9mm and have stuck with it, happily and confidently. So when my wife was ready, I had her follow suit. The semi autos just never clicked, her confidence dropped after every outing despite buying her 3 different pistols. She was at her wits end and enjoyed shooting as much as she enjoys giving birth. After I traded her last 9mm for a 357 snub, it was immediately shooting in the bull from first shot and hundreds of shots after, this is shooting 38 out of the Taurus .357 poly. I have since worked her up to a 110gr gold dot running between plus p 38 and 357 with a low report powder, took 500 plus rounds to get her there. So, long story short, 38 IS a good and even the BEST caliber for her to EDC.
Reason I do not PERSONAL LY feel its a good choice if you can sufficiently handle better. My first time shooting gel, I tried many times to get Fed HydraShok to expand from her snub (factory 38 loads and even +P) none expanded except for a couple half way(I'll find pics in my albums later), penetration in the 8-9" margins. Okay, not a new bullet design and there are many more, but looking for lpoads SHE could shoot. 90gr Honady lite, great expansion to the 8-10" mark and accurate, this was her carry for some time.
Laugh or cry, but I had an ND inside of out home because I couldn't keep my grubby hands of the interesting lockworks of her revolver(never owned one before, I "played" with it way too much) . laying on the couch, watching Television, I was cocking and thumbing the hammer down, over and over, like a real idiot. Gun goes off, incredibly quietly (wife five feet away and didn't even wake up, all the carpet and couches and whatever absorbed so much sound), anyway......shot the arm of the couch that had my thin leather jacket over it. I still wear this jacket, wore it today. It was folded so the bullet pierced the VERY THIN leather four times. Me and wife looked for the hole in the wall for hours.....never found it, nor in the couch. But did find the bullet, undeformed, sitting in the sleeve of my jacket. Still have the bullet, which could be reloaded and fired again, but kept on nightstand as a reminder to stop f&%$#ng with guns. I'll post pics