I'd carry my Glock 20 in 10mm, with a 4" 357 revolver as my 2nd choice. The 10mm outperforms 357 and is actually closer to 44 mag if the magnum rounds are shot from 4" or shorter barrels. When you step up to 6" or longer barrels then the magnum rounds are the winner. If I'm gonna carrry a handgun that big, I'll just carry a carbine.
My Glock is lighter, shorter, more accurate in rapid fire, more powerful, less recoil, less muzzle blast, more reliable in outdoor conditions, and holds nearly 3X as many rounds.