Well... I didn't stay in a Holiday Inn Express last night... so take it with a ...
grain of salt
I used to shoot alot of 357 mag at farm yard varmints through my 4" GP-100... you would think that any loading would be plenty for a skunk, racoon, rat, feral cat, or opposum... & yes pretty much any load does kill them with a solid hit, but just shooting to center of mass, there can be a very big difference in how fast the critter stops between a 110 - 125 grain bullet, & a 158 - 180 grain bullet... I used to swear by 158 grain hollow points, but honestly, I had alot of critters crawl off to cover to die, leaving me smelling them in the farm yard for several weeks to a month afterwards... there really is alot to be said for high velocity fluid shock... I found that switching to the faster light weight bullets caused the critters to stop moving in a much shorter time than than the slower heavier bullets, allowing me to clean up & saving my nose
but that was with realitively small critters... & then why wouldn't a 50 caliber ( used for example ) with a bullet designed to perform / rapidly expand do an equally or better job ??? how fast does the bullet have to go, to get that hydrolic effect... how big does the critter have to get before additional penitration is needed ???
While high velocity shock is a good thing it isn't everything...
back when I 1st started dating my wife ( many years ago now ) I started hunting with her dad & friends... being the new guy in deer camp, for the 1st couple years, I got to field dress the bulk of the deer ( I guess they wanted to make sure I knew how or something
) anyway I learned alot about wounds, buy looking at the amout of "blood shot" or bruised meat around the wound channel... one shooter shot a .243, almost everyone else up there shot 30-06, & the owner of the property a 300 Win Mag, ( I was the one that started out shooting the .243 ) & after getting "little gun grief" for several years, I switched to a Marlin 45-70... the .243 easily matched the 30-06 in bruised meat around the wound channel, even though the bullet was smaller in both weight & diameter... but the 300 Win Mag must have really been over kill ( if there really can be such a thing ) because it bruised meat several inches more, & sometimes as much as 5-6" from the wound channel, where bone was involved, while the .243 & 30-06 were normally more like 2.5 - 3"... my 45-70 while sounding like even more over kill, only bruised meat like 1.5 - 2" from the wound channel... but, while it damaged less meat on the dressed deer, it certainly wasn't any slouch at putting deer down, often slamming them to the ground on impact, something the .243 never really did for me...
so back to the handguns... what I learned dressing deer, coupled with my expiriences shooting varmints with the 357... yep those high velocity loads work... they do put the "smack down" on what they hit... but there is nothing magic about the 357, any cailiber capable of matching that bullet speed & of similar bullet design is going to do the job...
... personally I have a tendancy to gravitate towards the bigger bores, though I don't personally think typical bigger bore self defense handguns such as the 45 acp develope enough speed to get better shock performance than the small & light 357... but the magnum calibers certainly could & IMO do... but then there is also something that happens with those big slow bullets ( maybe is "how" the energy is transfered ??? ) but that 45 caliber bullet sure planted those deer... I'm betting a 45 acp with those "flying ashtrays" would plant a human sized target just like that 45-70 planted deer