I know I'll get some argument about this, but there are only two PROVEN handgun rounds that will give you a somewhat reasonable percentage of stopping a drug crazed, 180 pound, viscous attacker with one center mass shot:
Revolver - .357 Mag. Hollow points are best, but any will do.
Auto Loader - .45ACP. Again, hollow points are best, but any will do.
(maybe the .40 S&W - but I'm not convinced the rounds and weapons have been around long enough to be sufficiently proven yet)
From there we move into questions of expansion, recoil, blast, etc, etc, etc.
As someone posted - the shotgun is best. Point in the general direction and pull trigger. Lots of projectiles fly out, once they hit someting they stop.
But the original question was what's best in a .357 revolver. Since the application is presumably inside the confines of a home, I think the .357 is too much. Don't think so? - go to a dark room, put a fire cracker in a coffee can, light it and press it up to your ear. At the same time old out the other hand and with a camera pop off a flash bulb in your face. And at the same time have someone give you a light pop to the shoulder of the outstreached arm. That's a .357.
So what's best "in house" round that a .357 revolver will shoot. In my opinion something with reasonable bullet frontal area, something that won't make you deaf, something that won't blind you after the first shot, something that won't nail the neighbor if you miss.
I think that pretty much narrows it down to a .38. A 158gr LSWHP is PROVEN to be pretty good at one shot stops (short of .357's and .45's).
When it gets right down to it, anything is better than nothing. A couple of years ago a home owner in the area affected a one shot stop with a .25 Auto - through a door no less. Go figure. But it would seem that for "in home" defence, something you can handle, won't blind you won't make you go deaf and won't injure your neighbors or family members is the best option.