I think that you never even needed to ask the question (but we're glad you did anyway). Just look at the history of the cartridge, anything thats been around for 100 years and can still be found everywhere that they sell ammunition right along with the .22lr cant be too bad.
If you arm yourself with a .30-06 youll be set for any animal North America can throw at you (even the two legged kind). Just make sure you can put the bullet where it needs to go and you picked the right bullet.
