I'm on a 3-gun rule with my wife - that includes handguns and rifles. I've thought about it long and hard...
1) Concealed carry piece:
What I have is a Ruger SP101, and it's inconveniently heavy to pack on a daily basis. A Smith model 642 is on order, and luckily I'll be able to use my current .38's in it.
2) Open carry/home defense piece:
What I have is a shootable, but ugly condition Colt Python. Its barrel is undertwisted and its finish is poor. I'm going to sell it and pick up either a Smith model 60 5" or model 629 Carry Comp.
3) Plinking/small game hunting piece:
Don't have one yet. Thinking this might be a Ruger 10/22 or Marlin 70SS.
The other route is to go with a CCW, longarm for HD/OC, and a .22 pistol for plinking.