I have both, and love both. I handload, so my philosophy has always been 280 for longer (22"+) barrels, 7mm-08 for shorter ones.
SaltyDog said:7mm08 hands down. Its a great little cartridge and is capable of doing a whole lot more than most will give it credit for. I prefer the 150grn bullets as I get the best results accuracy wise from them. For deer, there is probably no better round out there, it has the best attributes of the .308 and the .243 mixed together.