I went through this same decision process many years ago. So I listed the pros and cons of each.
* The 22 Hornet is more powerful, but it is not a powerhouse by any stretch of the imagination, it launches a 40 gr bullet at about 2400 fps. The 22 WMR will launch the same bullet at about 2100 fps. So not a great big advantage.
* 22 Hornet is way more expensive to shoot than a 22WMR (about $1/round vs 30 cents/round for the 22WMR), and harder to find than 22 WMR.
* 22 Hornet is a 150-200 yds cartridge. 22 WMR is a 150-200 yds cartridge.
* Neither is really a good varmint cartridge, although either can be lots of fun to shoot.
What I ended up doing was selling my 22 Hornet and buying a 22 WMR instead for the intermediate size animals. But in reality, I shoot 22LR or 223 for just about anything of appropriate size for the cartridges. Now (30-ish years later), I have been given a 22 Hornet and am wondering what to do with it (too expensive to shoot very much, and a real pain to reload).
I'll have to disagree with a good deal of this. I own both the 22WMR and 22 Hornet.
22 Hornet factory ammo: 35gr Hornady V-Max is cruising at 3100fps. 45g Hornady SP is 2665fps.
22WMR factory ammo: 45gr Hornady is only 1700fps and that's from a 24", which most are shorter, and that's 965fps slower than the Hornet with the same weight bullet. 30gr Hornady V-Max is only 2200fps, still 465fps slower than the Hornet with a 5gr lighter bullet.
Simple fact is the Hornet is a good bit faster than the WMR with comparable bullet weights, which translates to more energy being delivered on target at the same distances.
Is the Hornet "way" more expensive than the WMR like this member claims? Ammo deals website search found the cheapest WMR ammo at $0.20/round. Cheapest Hornet ammo is $0.40/round. So this members statement of $1/round for Hornet ammo is WAY off. True, that Hornet ammo is actually exactly twice as expensive as WMR ammo. So unless you're a reloader, then WMR will always be more expensive. But if you reload, then you will quickly surpass the difference in price and then the Hornet will actually be cheaper than the WMR!
This member says neither are good varmint calibers. I think that's simply absurd! The Hornet has been a great varmint caliber for 87 years now with no signs of slowing. The WMR for about half as long, but still being a great varmint round at closer distances.
My opinion is that both guns have their place. There for a while, WMR ammo was impossible to find, right around the time of the 22LR ammo scare. Hornet ammo supply did not change really at all.
I use my WMR as a truck/atv/utv rifle when I'm running around my property. It's a Ruger American with a synthetic stock and a threaded barrel. I screw my suppressor on it for dispatching just about anything I see on my property that I don't like. Raccoons, possums, skunks, and crows. It's light, handy, and quiet with the suppressor.
My Hornet is a CZ 527 with gorgeous wood. I like to use it for target shooting due to the set trigger. It's scary how accurate it is. I plan on keeping it for my son to use for his first deer. I've got a couple friends that use a Hornet and those Hornady 45gr soft point bullets for taking meat deer every year. They swear by a Hornet soft point to the neck inside 125 yards.