I would assert that the correlation between KE and lethality/disabling is tenuous, at best. I would further assert that metrics like this are used simply because they CAN be measured, as opposed to because they actually provide meaningful insight.80 years or so ago the U. S. Army decided that it took a projectile with about 58 ft-lb ke to reliably produce a disabling injury. AFAIK, that number is still used in regards to anti-personnel mines.
That's about what you get with a 25ACP or 22 short pistol.
.22 LR doesn't magically "bounce around" inside the body. It cannot suddenly and radically change direction unless it hits bone.
Some people chose to carry .22LR handguns for self-defense. Unless you are very accurate with your weapon, we do not recommend shooting a .22LR for this purpose. The initial kinetic energy of such firearms is very low—you would be much better off with a .25ACP or .32ACP for roughly the same size firearm.
My great uncle was murdered by a friend, after his wife answered the door and had the visiting 'friend' wait on the porch. When my great uncle approached the door, at least 11 rounds of .22 LR were fired through the door. At least 6 bullets hit their target and most of them fully penetrated his body, lodging in the wall behind.notice barrel length was 18" on most Tell me again about 22 great penetration.