The only thing i dislike about frangibles is the fact that not all of your tweaker home invaders are hopped up freaks that are built like a prairie dog. You get a 300 pound scumbag wearing biker clothing and a layer of fat that would have made rosanne barr scream for mercy, and you may not ever reach vitals. You'll vaporize large areas of tissue, But your opportunity to blow out his heart, rip his lungs out, or chop his spine in half will not be there. I don't see the frangibles as a cartridge that you can fire a single or even double tap, and be reasonably certain that the encounter will be over.
Another thing about frangibles that I am very much concerned about.
When you blow a softball sized mass of a person's torso contents into an aerosol cloud, that's kind of worrisome. You're going to have blood and body fluids everywhere, even in the air you breathe, that are likely laden with Hepatitis C virus, HIV, syphillis, herpes, and other foul stuff that you don't want to make contact with. If you're wounded, you will possibly contract a lethal disease. Just cleaning it up is a scary proposition.
Don't underestimate the presence of these diseases among drug users. Hep C is as common as the cold, and blood contact is very risky.