I've had two .22-250s since the sixties, until this year, when I had my favorite re-barreled to .243 Win.
The Rem 700 ADL, (1980s vintage) IMHO is about the best Rem ADL made to date. In .22-250, it won me about a hundred turkey shoots, killed many woodchucks and crows, a couple of deer, and was exceedingly accurate, winning an informal inter-club 200 yard benchrest match. It would group 3/8" at 100 yards with my favorite handloads.
The two problems I had with the .22-250 were: For reloaders, cases stretched too much due to the body taper and trimming was a chore. I was using softer, but nicer Norma cases and had to trim after about every firing.
The second problem was even more frustrating. The twist rate of the Remington was 1/14", I believe, and it wouldn't stabilize any bullets over 55 grains. For a while in the 60s and early 70s, it was my only centerfire and though I was using Nosler 55 grain solid-based "Zipedo" bullets, it just wasn't a good deer cartridge for Maine hunting.
Many times, I thought of having the rifle re-chambered to .22-250 Ackey Improved, but was afraid the amazing accuracy of that barrel would suffer. I still have the used barrel and it's in good shape, but it will never be re-installed.
The .243 Win is everything I'd ever wanted in a Maine varmint/sometimes deer cartridge. It really does a number on eastern coyotes!
My Tikka .223 Rem is an even nicer range rifle than the .22-250 was, shading it for accuracy and the barrel doesn't heat up as much. It's also very tolerant of various loads and very easy to size.