Ruger x 2
If I plan to shoot a lot, as in plink, a Ruger Mk II standard model, 4". For years it was my only .22 handgun, and it carries well in a GI rig w/ .45 flap holster, web belt, canteen, and a FA pouch for extra ammo.
I have other .22's now, and my current GP favorite is a Single 6 with 6" bbl and the .22 mag cylinder. It is decidedly more punch for game, and I shoot the longer barrel better. The WMR ammo is to expensive to plink, but a few shots now and then won't break the bank. Volume single action plinking is sort of a bore, loading and unloading reduces shooting time and volume. It is a good way to slow down a trigger happy teenager.
If I just want a .22 along, and don't plan to plink or pot, a little Bearcat is no bruden to tote.
For some reason, I never came up w/ a DA .22 revolver.