They are like night and day different,,,
The two pistols are very different,,,
The noticeable difference is the frame size,,,
The functional difference (most important to me) is the action type.
The M&P is made to be a rimfire understudy to their full-size M&P in 9mm and .40 S&W,,,
It has the same large frame as the centerfire pistols.
The SR-22 is a compact pistol with a smaller frame than the S&W M&P,,,
S&W recently introduced the "American Made" M&P 22 Compact,,,
This new pistol is comparable in frame size to the SR-22.
The M&P is a internal hammer single action with a manual safety,,,
Once you chamber a round the action is cocked,,,
There is no way to "lower the hammer",,,
You depend on the manual safety.
The M&P 22 Compact operates the same way.
The SR-22 is an external hammer DA/SA pistol with a safety/de-cocker,,,
Once you chamber a round the external hammer is cocked,,,
You can use the safety/de-cocker to lower the hammer,,,
The first round will be a long pull with more weight,,,
Each subsequent round is fired in single action.
In my not-so-humble opinion,,,
The SR-22 is an ideal design for a .22 handgun.
Its frame size fits most people's hands very nicely,,,
And DA/SA with de-cocker is my personal preferred action type.
I do not like having a pistol that I cannot "lower the hammer" on a chambered round.
There are thousands upon thousands of people who say that's no big deal,,,
I'm not saying they are wrong in their opinion,,,
Just that I prefer a DA/SA with de-cocker.
My SR-22 has fired any and all types of normal ammo I have fed to her,,,
I have also experienced great proficiency with the pistol,,,
Its 3-dot sight is very visible and easy to aim.
I have two friends who shoot the full size M&P 22,,,
They don't seem to have any ammo problems either,,,
And their pistols have the same inherent accuracy as mine.
I like the idea of having two identical pistols with one shooting .22 and the other a centerfire cartridge,,,
In fact I collect those pairings and currently own 11 different sets.
I would own a M&P in 9mm and an M&P 22 if they weren't single action - internal hammer.
The Ruger SR-22 is what I recommend to new shooters wanting a .22 that is not a dedicated target style pistol.
Aarond
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