I'm in a different place, being firmly wedded to the .22 caliber, for many decades. .22 Hornet, .221 Fireball, .222Rem, .223Rem, & .22-250, in different rifles (and handguns).
No point for me to go to the .204, which doesn't feed from my existing stock of .22 bullets, and needs its own cleaning rod.
I've been using the .22-250 as my "top end" .22 since just before Remington standardized it. If you are in a situation where you can use it to its potential, there is nothing that can quite match it.
If not, then its a bit of a waste, and one of the smaller rounds (case capacity) if a better choice, both for efficiency and economy.
Also, you might find your choice of rifles different, due to the calibers.