I found that "Managed Recoil" slug ammunition to be inaccurate (as in I ran out of it before I could figure out whether it was shooting high or low or what). Before I shot it and after I shot the "managed recoil" slugs, I shot the standard load slugs and was ringing the plate without missing at 50 yards. I know we are talking about home defense distances here, but I lost all confidence in the "managed recoil" niche of ammunition. Your experience may differ.
Pattern your shotgun with what you will actually use in it and practice with that.
Know on sight what kind of pattern your gun will produce at the various distances you might use it. Different ammunition can produce significantly different patterns, some quite tight and others rather loose. I prefer tight, but you should at least know what you are going to get.
If the shotgun is to be your primary home defense gun, then you should practice reloading that shotgun until you can do it without any hiccups. While it may be that you never use it at all, or if you do use it that one or two rounds will suffice, you must be able to reload that gun quickly and flawlessly. I took a shotgun class and realized quickly that the shotgun is the .357 magnum revolver of the long gun world - lots of sound and fury, deadly ballistics, and six rounds before that deafening "click" of an empty gun.
What a shotgun gives you is devastating power and a pattern of projectiles, the tradeoff you make for that is low ammunition capacity. Reloading a shotgun is a critical skill, and much more dependent upon practice than dropping a magazine and inserting another.