I think I would add that if your thumbnail indents them equally for equal applied pressure and unless one is significantly better made than the other, you will be hard put to see a difference. If they are different hardnesses, the softer one will shoot slower because it doesn't offer as much resistance for the powder to build pressure against. But will it have a different POI? That depends. If it's used at a long-range (say, 100 yards), it will impact lower. At a 25 yard target, though, it won't be a big drop difference in a self-loader, and a revolver may actually compensate some for the lower velocity by recoiling up a little further in the longer time, the slower bullets take to clear the muzzle, thereby landing them in the same spot. I've seen that effect as far as 50 yards out, but by the time you get to 100 yards, slow has dropped more significantly.