drobs
It seems to me the best thing, would be to buy an assembled gun of the caliber you want, on sale at Cabelas. On the few pistols that I have, the pin locations seem to vary and the fit of barrel to frame can be tight, even on a supposed matched unit.
After you insert the cylinder pin into the barrel section, and then if you find that the two locating pins don't line up with thier holes, you will need to start filing the tight sides of those pins to make them fit. You could also try relocating the holes in one side or the other, but you better have some machine shop capabilities for that. Just replacing a broken pin can be a hassle.
And what if the frame to barrel contour is not smooth...more grinding or filing. Maybe I'm just not lucky, but I can't see opening that can of worms. There seems to be things to fix on even an assembled pistol. I like to fix things, but it's nice when you don't need to fix things and can just shoot.