I've owned two different P250's, both in 9mm....a compact and a sub-compact. Neither ever gave a single problem. I put over 2000 rounds through the compact and around 1800 through the sub-compact, while I had them. What else can I say ? They were both accurate and the triggers were wonderful. Maintenance was a breeze, due to the removable fire control "chassis".
The magazines were first class....never a single problem of any kind.
The P250 is a bit chunky, at least that is the way it seems, but concealment was no problem, especially with the sub-compact.
The bore axis is rather high. But, that never seemed to affect my shooting negatively, enough to matter anyway.
The only problem I ever had with them was the fact that, if I didn't practice with the P250 more or less every week, I would get "rusty" with the trigger....and would have to expend 40 or 50 rounds in order to get back "into the groove", so to speak. I suspect that this problem had to do with shooting other types of pistols in the same time frame - so I am sure that it was MY problem - nothing to do with the gun. If one used the P250 all of the time, I seriously doubt that such an issue would ever arise. For other, more versatile shooters, this sort of issue probably never comes up, anyway. (As I said, I'm sure that it was MY problem.)
I finally gave up the P250's because of this issue and because I wanted to continue to shoot other types. I have since gone back to only revolvers, my first love. Oddly enough, despite the trigger similarities to the P250, I've never had this kind of issue with any revolvers.
Of all of the autos I have had, I miss the design and simplicity of the P250 the most. I have always regretted that Sig has never proceeded with this design further....such as a single stack sub-compact version, etc. The P320 is a different animal, though it uses the same grip frames and looks very similar.