Welcome to TFL RileyMartin.
To answer your question: It depends on your . . .
. . . ammunition purpose, and bullet weight. And other ancillary factors.
Someone mentioned TiteGroup. TG will work well with plated or jacketed bullets, but it runs too hot for lead. It's also pretty fast, so I'd steer clear of heavier bullets (180gn or more) with such a spunky propellant - especially if you're a novice loader.
In general, the new loader should probably start with a propellant that's a touch slower - something in the "intermediate" category.
If you are new, HS-6 is a great choice. It meters VERY well so that you don't have to fear an overcharge as much. Also, it doesn't seem to spike up pressure as quickly, it's more linear, and therefore more forgiving. It also burns clean nearer to maximum.
I agree. Completely. HS-6 is an excellent choice for the novice loader. It meters well. And it behaves more predictably - more linear, as Mississippi describes - than many other propellants. It tends to like heavier bullets, but as a new loader, it's better to start with lighter ones. Lighter bullets buy you more forgiveness. 165's are a good way to go with 40 S&W all-around. If you wanna go 180's, I recommend getting some 'xperience first. Cut your teeth with 165's and an intermediate propellant.
With more information - your load purpose (basic range ammo; high-recoil practice; self-defense; sport shooting; pure target; etc.), what bullets you are thinking about using, etc., we'd be able to give more specific answers.
Load safe.