I have a model 60 in 357 with the 2 1/8 inch barrel and 2 finger grips, and the 340sc in 357 with the 1 7/8 inch barrel and the 2 finger grips (can't help much with the LS, though in addition to what has been said above I think it comes in a special case). The 60 is a pleasure to shoot in 38, and a little rough in 357. The 340, on the other hand, is rough to shoot with 38, and slightly painful in 357 (when I say slightly painful, I mean after shooting a cylinder full, you're hand is slightly numb and tingling). They both shoot the same caliber and hold 5 rounds, so no difference there. Where the 340 has the edge, however, is in the much lighter weight. If you're buying the gun primarily as a range or home defense gun, go with the 60, but if your primary purpose is CCW, go with the 340. Also, do yourself a favor and buy a Galco Ankle Glove for whichever gun you buy. My 340 in a Galco Ankle Glove is my favorite carry combination. You can actually forget you have it on.