The M25-2 is a wonderful piece, and if mine is typical, as accurate and powerful as any 1911, including customs; with the advantage of capability with an effective SWC bullet and no feeding worries. But that thin cylinder wall has to make you cautious. I've loaded a few 260-grain .45 Colt slugs (the Lyman #454424) with Unique to mid-900 fps velocities in Auto Rim cases, and that's about as far as I'd like to go...mostly I use the 200 gr. SWC #452460, sized to .453", over 4 grains of Bullseye pr 7 grains of Unique, the Lyman book load. This produces gratifiyingly small groups to 50 yards and has plenty of power for a .45 ACP. I'd never use the 25-2 for hotter loads...isn't that what the Ruger .45 Convertible and T/C Contender are for?