I disagree with the comment that reliability is less important in a Home Defense gun.
If you have a family, and you're depending on that gun to be the barrier between them, the person or people who may want to hurt them, and harm, are you willing to say that absolute, 100% reliability is not as important as in a personal carry weapon?
On the contrary, in that situation I say that reliability is all the more important.
In ANY firearm used for personal protection, 100% absolute reliability is the single most important factor there is.
Everything is is secondary, such as:
Not as accurate as your other guns? Who cares? Unless it's shooting 4-FOOT groups at 10 feet, a few inches spread at 25 yards on a close-in defensive weapon is not a big deal.
Not quite as easy to use? That's what training, and LOTS of training, is for.
Kicks more than your other guns? Again, training, but with the plethora of ammo and grip options that are out there today, it's not going to be hard to get things under control.
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Beware the man with the S&W .357 Mag.
Chances are he knows how to use it.