By and large, the 100-grain bullets in .243 have a bit thicker jackets, so they are less likely to "blow up" and make a shallow wound. They are pretty much the accepted deer load.
I've killed some 20 or so central Texas whitetail, field-dressing at around 90 to 110 pounds; I've used the Sierra 85-grain HPBT in my handloads. Federal makes the same load, in recent years.
FWIW, Art