A few months ago I was considering a single action to go along with my Buckmark auto.
My brother in law has a nine shot revolver, which he let me try out. I then looked at all the different makes.
The more I looked the less I wanted one. The tedium of the revolver's cylinder unloading/loading, the double action trigger, the sights, all became more and more bother than fun.
I didn't get one.
To be totally open, I did buy a GP-100 which lasted only two months-the more I shot it the less I liked it. Just the opposite is the case with my Buckmark and Makarov.
In summation: my advice is try to determine what KIND of shooting you think you'll like, either wheelguns or auto loaders. Then make your decision.
BTW-my son in law has a 22/45 and he really likes it! I've shot it and I like it too.