A small weight variation like that shouldn't cause flyers on the order of magnitude you're describing.
And a 5 grain spread is fairly common for multi-cavity Lee molds, especially if you kept all of the bullets from as soon as they dropped in good shape, on up to running so hot everything was frosty and crystalline. If the variation was partially caused by heat, you should see different diameters as well - even from the same cavity.
I'd say the accuracy issue is likely due to another factor, not the mold or alloy.
Anyway... as for tracking down basic mold problems:
If your mold is the
older style with V-notches and cross pins for mold block alignment, it may be a mold that doesn't align well. I have a few of these that, after substantial "massaging" and adjusting, still require very careful alignment by hand for every single poor. I can't just close the blocks, swing the sprue plate back, and cast away. I have to align the blocks, jiggle, wiggle, twist, and shift; then close the sprue plate, recheck, and give the blocks one more adjustment (and then hold everything very tight, so it doesn't move).
If it's the newer style (
example), check to see if you've gotten lead splatter anywhere between the mold blocks and make sure your alignment pins are seating properly. The newer molds use notably higher quality materials and are a better design. (Still sub-par, in my opinion, but far better than the old molds.)
Mike's advice on temperature is exactly where I ended up after a lot of experimentation: Start at 720/725 F, and see how that works.
Generally, that'll run almost any Lee mold with almost any alloy, once you get the mold up to temperature. If that doesn't work, check the mold for problems again. And if that is not fruitful, try a little more heat (in the alloy
and the mold blocks).
My Lee molds usually have to be running so hot that almost all bullets drop frosty, in order to stay consistent and usable (by my standards). Even then... each cavity is different in every one of my Lee molds (different diameter and weight), and each mold has its own additional set of problems to deal with - such as bad sprue plates, cavities that don't like to release, cavities that hang up with extra heat, cavities that 'hot spot' regardless of temperature, etc...