I use Lee Autodisk powder measures on all the turrets for my Lee Turret Press. I currently have four turrets set up, ready to swap out for when I want to change what I'm loading. That said, I have no interest in customizing even one hole in one disk to achieve the "perfect" load for one particular caliber, bullet weight, powder type, and velocity. I would go nuts buying, modifying, and trying to keep track of disks.
For example: I load for handguns, and except for some cowboy loads using Trailboss I load everything with Winchester 231/HP38. In .45 ACP, I go from 230-grain round nose to 200-grain semi-wadcutters to 185-grain round nose. In 9mm I may load a 100-grain round nose, a 115-grain round nose, or either of two 124-grain hollow points. That's potentially seven different apertures just to cover two "calibers" with one powder.
Thanks, but no thanks. Too complicated for me. If one of the standard apertures gets me a mid-range loading for the caliber and bullet weight, that's good enough for me. If I were shooting bullseye, it might be a different story. If I were shooting bullseye and I were competitive, it almost certainly would be a different story ... although, even then, I think round-to-round consistency is probably more important than achieving some particular velocity to the last digit of feet=per-second.
For those who must dial in loads more accurately that the pre-set apertures allow, Lee offers the Adjustable Charge Bar. I have one, but I don't use it because I haven't (yet) found a need for it.
https://leeprecision.com/adj-charge-bar.html
It's cheaper than a box full of modified disks, and you only need to buy it once. It's calibrated, so it's repeatable. And if you make a mistake, it's reversable.