Sig P220 conversion to 10mm...
Yes, the breech face on the slide of the .45 ACP would be too large in comparison to that of a 10mm cartridge.
Now, if the .38 Super slide could/would fit to that of the new ST frame, I believe that all that would be required is a slight machining of the breech face to accomodate the 10mm cartridge (.406" vs. .425" respectively).
C.O.L. of the .38 Super is actually listed (in the latest Accurate Number Two loading guide) as longer than that of the 10mm, so feed angle may be okay. However, the case length of the 10mm is some .090 longer than that of the .38 Super, so the ejection port/ejector length may have to be examined in consideration of proper ejection of fired cases. Not sure on all this, as I've never been involved in this type of conversion. Anyone out there that has done this, it would be really great to here about it!
Then again, Sip P220 .38 Super collectors may consider it sacrilege for this to be performed, as I don't think that too many of these pupies may be around anymore.
Still, an interesting thought on the 10mm in a Sig body... I'd really like to see it!