As a rule of thumb cast bullets should be .001 over bore diameter, so in your 45 ACP that would be .452, a lot has to do with the lube mold you are talking about, if it’s a Lee push threw, I would go with the Tumble lube Mold, But then again a lot has to do with the gun its self. I have bought and sold dies to get a bullet the gun liked.
I use a Lyman lube/seizer, and have found very few Lee molds that work to my standards; with the Lyman L/S. this is not bashing Lee molds.
An example of this, recently I was working up a 45 Colt bullet, I opted for a lee 250 grain Lee mold, and they shot very well. But with the Lyman 450, two things are needed. One deep lube grooves, and also a larger base, which Lee has neither. So I ended up buying a Lyman mold, problem solved.
I know several guys that use Tumble lube with the standard non- tumble lube Lee molds with good results.
I am not a fan of the Alox lube, just to tacky for me, I have cut it with mineral spirits and it works better.
But it’s all in what works for you and the gun.