For whatever its worth, a friend of mine from years aback was left handed, and his pick of revovlers was the S&W Model 29. I watched him shooting and reloading, and if there was a problem, it didn't show.
After firing, he released the cylinder latch with his index finger and pushed the cylinder out with his right thumb. He then swung the gun around so the muzzle was pointing straight up, butt facing him, and punched out the empties with his right had. Then swung the gun around again, holding the cylinder open and the gun turned sideways, cylinder up, and reloaded the gun. As I remember he closed the cylinder by reaching over wit him right hnd and pressing it shut.
His gun handling of "swinging" the gun around never allowed the gun to point in an unsafe direction nor allowed the open cylinder to flop around in any way.
Bob Wright
Not only was this man left handed, he was also a deaf mute. We communicated at the range by writing notes. Despite his handicap, he had taken two deer and one coyote with his Model 29.
BW