You know the important stuff already.
Don't underestimate the ability of load changes to alter the POI.
Bullet weight and burn rate!
Now,honestly,if its 4 in high at 25 yds,its a perfect 6 oclock hold on an 8 in bull,or steel plate.You'd still be on a beer can.
Where is it at 50 yds?
On figuring "How Much" its really simple.The unit of measure that matters is your sight radius.
You will probably measure that in inches.That works fine.Then you need to know the range to the target in inches.You have to have a common unit to work with.25 yds,36 in to a yard. So,25 times 36 equals 900 inches.
I'm going to guess your sight radius at 7 inches.You have to measure it.
So,we divide the sight radius in inches,into the range in inches.900 divided by 7 equals 128.57. If you want to round that to 130,no big deal.
So it is 130 sight radius "units " to the target.
That meansany change you make to the sights will be multiplied 130 times,approx.
So,.010,ten 1 thousandths,would be 1 .3 in on target. Then .030,thirty thousandths,would give you 3.9 in on target. .03125 is 1/32 in.Pretty darn close.
You probably have 1 MOA clicks. At 25 yards,it would be 4 clicks for 1 inch.
If .010 is good for 1.3 in,I'd say .010 is pretty much good for 5 clicks.
Myself,I can see being up 5 clicks for flexibility,but I'd want most of my adj left for longer range.I would not center my adj at 25 yds,myself.
Ideally,a .040 change is what willgive you what you want.
But,.020 is not so much.That would give you a 2.6 in change,bottomed out.
.020 off the top of the rear sight blade can work.So,bottomed,you would only be 1.4 in high at 25 yd.Probably real good at 50.
Don't forget,my numbers are based on a wild guess of your sight radius.Measure and refigure.