Spouts are only a nominal representation of the volume that a given weight of powder has. Ideally, a 25 grain spout would throw a charge of powder that weighs 25 grains; but that isn't always the case (probably is rarely the case). Granulation, formulation, and quality of ingredients all factor into the weight of powder.
If you want an exact 25 grain load of powder, you would need to weigh out 25 grains, then cut your spout to hold that much. Of course, your next can of powder may not equal 25 grains by weight using that same spout.
FM