Wild, a lot of folks do a lot of things. The amount of success depends on the amount of skill and the knowledge brought to the effort.
Look: The last mulie I killed was rudely awakened by me from his noonday nap. I was no more than thirty yards from him. I had what seemed to me to be "all day" to judge whether or not to kill him. I could as easily have center-punched him between the eyes with a .22 rimfire as ruining his neck with my '06. But I've been hunting and shooting for over 65 years. I'm supposed to be able to do the sneaky-snake thing, and hit exactly where I intend to.
hunter 33, by the very nature of his question, seems to be one who is starting out, still on the upside of the learning curve. I'd bet that he still has to learn to deal with all the bits and pieces of that learning, to develop the knowledge and skill that is needed for success at that proverbial clean and ethical kill. I figure he can stay with it, work at it, and do just fine.
This is no reflection upon him, of course. We all go through it. I did, for sure. So did you, Wild, just as you went up a learning curve in gunsmithing. We all gotta start somewhere...
Just as folks don't move from trundling around town in their little Honda to driving a Formula 1 car, folks shouldn't start off in hunting with cartridges that demand an expert's higher level of skill.
My 2¢, anyhow.
Art