Any ammo sold 8 to a package makes me nervous! And part of my resistance is the fact that at 8 to a box you are being discouraged from practicing with them, which is insane. How do you know your auto will feed and eject them? How do you know they'll properly extract from your revolver? The 20-per-box packaging allows you to put half through the gun at the range and still have a loaded clip ready for defense.
I like Hornady Critical Defense (and their other defense rounds), Federal Hydro-shock and the Cor-Bon +P series, all of which have good data on penetration and expansion (and generally are testing to FBI standards). For larger calibers I avoid standard JHP that are not designed for personal defense as they tend to be either too hot or too slow to expand.
Where these fully-disenigrating rounds like the Glaser might make sense is if you're trying to avoid full penetration with a caliber that's basically too big for personal defense, like a 44 Mag or a hot 45 Colt, since a fully-expanded bullet is generally more lethal than a fully penetrated one, and the risk of collateral damage is eliminated. In some states defending yourself with an inadequately expand large caliber round that fully penetrates and hits a bystander is de facto negligence, as well as impolite.